This study examines the relationship of e-procurement i.e. e-payment, e-tendering, e-invoicing and e-customer relationship management on supply chain management. It is observed that previously it is quite a time consuming activity as well as it is inefficient too. With the introduction of e-procurement, the overall process can be less time consuming as well as it is also very much efficient in order to do all procurement related activities in a timely manner. In this research it has been analyzed that E-procurement is a key role in future for companies as there are many companies already switch their supply chain management process into e-procurement activities as in the studies it has been analyzed that the previous studies show how important e-procurement but not provide the empirical and theoretical impact of e-procurement implementation in supply chain management and performance. Present studies attempt the best possibilities with the effect of e-procurement steps which are in practices in supply chain process in Pakistan and manufacturing sector. Through the help of SPSS software able to find the impact of supply chain with e-procurement variables has a positive impact on supply chain management and results are agreed with the findings of research. The results show that the four electronic variables of E-Procurement are essential factor which directly reduce uncertainty in supply chain functions increase supply chain activities and practices, fast moving process, fast moving supply chain order, fulfillment of orders with quick and improve supply chain performance.