Poverty is a global challenge that encompasses not only economic hardship but also limited access to basic necessities and opportunities for a better life. The study empirically investigates the impact of inflation on poverty in five Asian countries: Pakistan, India, Sri Lanka, Bangladesh, and Nepal over a period 2001 to 2021 by using various statistical techniques, including panel unit root tests and Pedroni cointegration tests. The analysis revealed strong connections among the selected variables, indicating that while inflation does not directly cause poverty, it does influence income, purchasing power, and economic stability, potentially leading to higher poverty rates, especially among vulnerable populations. The study also considered other factors such as political instability, corruption, and GDP per capita, which were found to be significant in shaping poverty levels in these countries. Bidirectional causality was identified between population growth, GDP per capita, political instability, and poverty. However, no significant causal relationship was found between corruption, the Consumer Price Index (CPI), and GDP per capita in this context. Findings of the analysis underscores the vital role of effective governance, economic stability, and targeted policies in alleviating the negative impacts of inflation on well-being. To achieve sustainable development goals, especially those focused on poverty reduction and improved health, a comprehensive approach that considers these interconnected factors is essential.