Strategic orientation enables Small and Medium-Sized Enterprises (SMEs) to optimize their profits and performance through strategic decision-making. In order to identify strategic orientations that influence the performance of small and medium-sized enterprises (SMEs) and small ventures, a systematic review is undertaken. The review has identified a conceptual framework for strategic orientation that has the potential to assist small and medium-sized enterprises (SMEs) in risk mitigation, marketing effort optimization, adoption of cutting-edge technologies, experimentation with novel ideas, and the development of profit margin-maximizing plans. This study contributes to the extant literature and establishes a foundation for subsequent research investigations.